Job Description
Are you a motivated scientist passionate about computational chemistry and keen to contribute to drug discovery? Grab the opportunity to work in the heart of the Bay Area's biomedical community at our company's state-of-the-art research laboratories in South San Francisco!
At our company, we are revolutionizing healthcare. We believe that innovative, research-driven, and scientifically backed projects can deliver drugs that will save and improve lives around the world. Our legacy is one of breakthroughs and advancements in the world of healthcare and medical research. Now, we are looking for an exceptional individuals to become part of our team and continue adding to our legacy.
About Us
Our company's Research Laboratories South San Francisco, a wholly owned subsidiary of our company is a thriving hub for discovery research. Located in the heart of the Bay area's biomedical community, our research ranges from exploratory biology to early clinical development. We work on diverse modalities - small molecules, peptides, bioconjugates and biologics. Our laboratories are an integral part of our company's influential network of drug and vaccine discovery.
Join our diverse, inclusive, respected, and collaborative organization where every employee contributes to our critical mission of discovering drugs. At our company's Research Labs South San Francisco, you'll have the opportunity to expand your knowledge, develop your skills, and advance your career while working with the best minds in the industry.
The Role
We are seeking an extraordinary, motivated, and curious scientist for our Modeling and Informatics group. As a Senior Scientist (R3), you will be part of a multidisciplinary team, collaborating with Medicinal Chemists, Structural Biologists, Pharmacologists, and Biologists in a highly collaborative environment. Your role will be pivotal in advancing drug discovery projects and innovating medicines to improve patient's lives. Do you have an insatiable appetite for learning, applying advanced computational techniques, and developing innovative computational methods? Then, you are the person we are looking for.
Preferred Experience

• Familiarity with one or more molecular modeling packages such as MOE, Schrodinger, OpenEye
• Proficiency in applying computational methods such as molecular dynamics, quantum chemistry, and machine learning to biological problems
• Cheminformatics to analyze and understand data

Key Responsibilities

• Collaborate with multidisciplinary teams to discover new drugs
• Spearhead the modeling and informatics initiatives on project teams, strategically applying computational methodologies throughout all stages of the drug discovery process.
• Utilizing various informatics and modeling techniques to analyze large datasets and accelerate the evolution of drug discovery leads to drug candidates.
• Engaging in research in areas of molecular modeling relevant to drug discovery and maintaining an external scientific presence through significant scientific publications and presentations

Qualifications
Required Education:

• Ph.D. (or near completion) in Biophysics, Chemistry, Biochemistry, or equivalent. A degree with a computational chemistry emphasis is preferred.

Required Experience:

• Programming/scripting proficiency in Python, including experience manipulating large datasets
• Familiarity with Linux and high-performance computing
• Strong written and oral communication skills, and ability to work well in multidisciplinary teams
• Evidence of creative application of computational chemistry approaches to problems of biological interest, demonstrated through multiple publications and external presentations

Preferred Experience:

• Experience applying computational methods such as molecular dynamics, quantum chemistry, and deep learning to problems of biological interest
• Experience with lead identification and lead optimization of diverse therapeutic modalities
• Ability to use molecular modeling packages such as MOE, Schrodinger, and OpenEye

• Have experience with Cheminformatics tools such as Spotfire to analyze and visualize the data
• Excited to learn and implement novel technologies including AI/ML to advance the pipeline
• Experience working in multidisciplinary teams that include experimental scientists.

The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives.
Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for us all.
Our company is an equal opportunity employer,Minority/Female/Disability/Veteran - proudly embracing diversity in all of its manifestations.
NOTICEFORINTERNALAPPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.
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We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
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U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.
Expected salary range:
$151,900.00 - $239,200.00
Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here .
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
10%
Flexible Work Arrangements:
Not Applicable
Shift:
1st - Day
Valid Driving License:
No
Hazardous Material(s):
N/A
Required Skills:
Data Science, High Performance Computing (HPC), Machine Learning, Researching, Scientific Modeling
Preferred Skills:
Job Posting End Date:05/31/2024
A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R293322