Director, Pharmacometrics

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Director of Pharmacometrics will support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making from compound nomination through first‑in‑human studies. This role involves conducting PBPK and/or QSP modeling directly or working with external partners on a case‑by‑case basis to integrate preclinical, in vitro, biomarker, and early clinical data into predictions that inform IND‑enabling work, dose selection, and study design.
 

Working closely with translational development, DMPK, biology, toxicology, and clinical teams, the Director will help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights. In addition to mechanistic modeling activities, the Director will provide scientific review and strategic input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners. This position is well‑suited for a scientist who enjoys hands‑on modeling balanced with coordinated vendor support, and who thrives in a collaborative cross‑functional environment.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Lead mechanistic modeling (PBPK and/or QSP) to support IND‑enabling decisions, FIH dose selection, and early clinical strategy.
• Integrate preclinical, in vitro, biomarker, and early clinical data to generate human PK/PD and dose predictions.
• Partner with translational development, DMPK, biology, tox, and clinical teams to anticipate quantitative needs across key decision points.
• Provide strategic oversight of population PK, PK/PD, and exposure–response analyses conducted internally or by CROs.
• Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy.
• Develop and review program‑level quantitative analysis plans.
• Synthesize modeling results into clear, actionable insights for project teams and governance.
• Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs).
• Support departmental objectives, mentor staff, and help build internal mechanistic and translational modeling capabilities.
• Strong written, presentation and verbal communication skills.
• Other duties as assigned.

Education and Experience:

Required:

• Pharm.D/Ph.D. or MS in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a strong understanding of clinical pharmacology principles.
• Significant industry experience (Director: MS and 10+ years of experience) in clinical pharmacology data analysis and interpretation.
• Experience with PBPK modeling, QSP modeling, and/or integration of AI/ML into clinical pharmacology decision-making.
• Experience interpreting and overseeing population PK and exposure–response analyses.
• Familiarity with all stages of clinical drug development, including experience in the preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND- and NDA-stage projects.
• Experience working in a cross functional team and matrix environment.
• Strong written, presentation and verbal communication skills.
• Ability to influence business leaders at all levels.
• Critical thinker with strong problem-solving skills.
• Demonstrated leadership, strategic thinking, collaboration, and management skills to oversee and develop in-house pharmacometrics capabilities.

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Travel:

You may be required to travel for up to 5% of your time.

Equal Opportunity Employer:

Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.

Salary Range

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.