The Senior Manager, Safety Support Lead oversees service delivery management for a defined application portfolio, ensuring performance and operational excellence while leading a team. They drive continuous improvement using automation and AI, manage finances, and collaborate with stakeholders to maintain a high-performing application portfolio.
ROLE SUMMARY
The Senior Manager, Safety Support Lead, is responsible for end-to-end service delivery management of a defined application portfolio, ensuring performance, availability, quality, and financial stewardship. This role combines technical service ownership with people leadership, managing a team of Application Service Delivery Management (ASDMs) to deliver operational excellence and continuous improvement across the Safety portfolios in support of a global user base.
Will drive continuous improvement and innovation, leveraging automation and AI to enhance operational efficiency. Collaboration with infrastructure, platform, and business stakeholders is essential to maintain a stable, future-ready application portfolio.
ROLE RESPONSIBILITIES
BASIC QUALIFICATIONS
PREFERRED QUALIFICATIONS
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Other Job Details:
Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [email protected] . This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
Information & Business Tech
The Senior Manager, Safety Support Lead, is responsible for end-to-end service delivery management of a defined application portfolio, ensuring performance, availability, quality, and financial stewardship. This role combines technical service ownership with people leadership, managing a team of Application Service Delivery Management (ASDMs) to deliver operational excellence and continuous improvement across the Safety portfolios in support of a global user base.
Will drive continuous improvement and innovation, leveraging automation and AI to enhance operational efficiency. Collaboration with infrastructure, platform, and business stakeholders is essential to maintain a stable, future-ready application portfolio.
ROLE RESPONSIBILITIES
- Lead and develop team of ASDMs: Oversee individual contributors, fostering a culture of excellence, collaboration, and continuous professional growth within the Enterprise Architecture and Support organization.
- Ensure application reliability and performance: Maintain and optimize the portfolio of systems supporting the Regulatory and Medical business units, ensuring high availability and performance to meet critical business objectives.
- Seek opportunities for automation: Promote the identification, design, and implementation of automation solutions including traditional, self-service, and GenAI capabilities to enhance operational efficiency and service quality.
- Manage financial stewardship: Oversee budgeting, forecasting, and financial management activities to ensure responsible allocation of resources and achievement of financial targets.
- Partner for lifecycle management: Collaborate with creation center teams and business stakeholders to recommend end of life upgrades and retirements.
- Support compliance and audits: Ensure readiness for audits and inspections by maintaining robust controls over computer operations, access management, and change processes.
BASIC QUALIFICATIONS
- Bachelor's degree in Information Management, Computer Science, Engineering, or Technology Management or a related field
- Minimum 7+ years of progressive experience in information technology, including roles such as architect, business analyst, software developer, systems administrator, database administrator, systems engineer, support specialist, technology team lead, or manager
- Experience and demonstrated competencies in working with teams in a matrixed organization, building strong relationships and driving successful cross-functional outcomes
PREFERRED QUALIFICATIONS
- Experience managing systems supporting pharmaceutical operations or other highly regulated environments
- Experience across multiple R&D domains including Research, Clinical, Safety, Regulatory, and Medical
- Expertise in automation and AI-driven solutions
- Experience leading global or multi-site teams
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
- Travel may be required as part of this role. Expectations around travel will vary but candidates must be capable of travel.
- Pfizer Digital & Technology is a 7x24x365 endeavor. This role may require physical or virtual participation on a weekend, holiday, or after normal business hours.
Other Job Details:
- Last Date to Apply for Job: 3/26/2026
- Work Location Assignment: Must be able to work from assigned Pfizer office 2-3 days per week, or as needed by the business
Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [email protected] . This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
Information & Business Tech
Top Skills
AI
Application Service Delivery Management
Automation
Computer Science
Engineering
Information Management
Technology Management
Pfizer New York, New York, USA Office
Pfizer Hudson Yards Office



66 Hudson Blvd E, Suite 20, New York, NY, United States, 10001
Pfizer Madison, New Jersey, USA Office
1 Giralda Farms, Madison, NJ, United States, 07940
Similar Jobs at Pfizer
Artificial Intelligence • Healthtech • Machine Learning • Natural Language Processing • Biotech • Pharmaceutical
Responsible for scientific oversight and quality of late-stage oncology clinical trials, partnering with colleagues to ensure successful execution, protocol authoring, and data analysis.
Top Skills:
MS OfficeScientific Software
Artificial Intelligence • Healthtech • Machine Learning • Natural Language Processing • Biotech • Pharmaceutical
Provide scientific oversight and data quality for late-stage oncology clinical trials; author protocols and regulatory documents; analyze emerging safety and efficacy data; partner cross-functionally to execute phase 3/pivotal programs and support regulatory submissions and governance.
Top Skills:
MS Office
Artificial Intelligence • Healthtech • Machine Learning • Natural Language Processing • Biotech • Pharmaceutical
The Program Lead manages oncology medical affairs through strategic program oversight, stakeholder alignment, and operational accountability, ensuring timely execution of medical deliverables.
Top Skills:
ExcelMicrosoft ProjectPowerPointProject Management Tools
What you need to know about the NYC Tech Scene
As the undisputed financial capital of the world, New York City is an epicenter of startup funding activity. The city has a thriving fintech scene and is a major player in verticals ranging from AI to biotech, cybersecurity and digital media. It also has universities like NYU, Columbia and Cornell Tech attracting students and researchers from across the globe, providing the ecosystem with a constant influx of world-class talent. And its East Coast location and three international airports make it a perfect spot for European companies establishing a foothold in the United States.
Key Facts About NYC Tech
- Number of Tech Workers: 549,200; 6% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Capgemini, Bloomberg, IBM, Spotify
- Key Industries: Artificial intelligence, Fintech
- Funding Landscape: $25.5 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Greycroft, Thrive Capital, Union Square Ventures, FirstMark Capital, Tiger Global Management, Tribeca Venture Partners, Insight Partners, Two Sigma Ventures
- Research Centers and Universities: Columbia University, New York University, Fordham University, CUNY, AI Now Institute, Flatiron Institute, C.N. Yang Institute for Theoretical Physics, NASA Space Radiation Laboratory




