Senior Scientist- Innate Immunity & In Vitro Modeling

Why Patients Need You
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.
What You Will Achieve
As a Senior Scientist in Viral Vaccines group, you will spearhead groundbreaking research dissecting the early innate immune mechanisms that shape vaccine efficacy and reactogenicity. By leveraging your innovative mind and deep expertise in immunology, you will lead projects to uncover novel immunological mechanisms driving vaccine efficacy, and investigate/develop new models to drive vaccine selection and understanding. Your work will directly contribute to the discovery of new vaccine targets and the optimization of immunogenic formulations, ultimately advancing our mission to deliver life-saving vaccines and improve global health outcomes.
How You Will Achieve It

• Regularly contribute and influence at the project team level.
• Design and execute experiments to profile innate immune responses to vaccine candidates, driving candidate selection and advancement.
• Develop in vitro and ex vivo assays and models to validate biomarkers predictive of vaccine efficacy and reactogenicity.
• Develop, optimize, and perform flow cytometry and multiplex cytokine assays to support preclinical studies, and evaluate new models.
• Supervise junior colleagues in design and execution of experiments.
• Identify, trouble-shoot, and optimize relevant assay systems, technologies, and readouts.
• Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetings.
• Effectively collaborate with other members of Vaccine Research & Development and supporting partner lines.

Qualifications
Must-Have

• PhD in Immunology 0 to 4 years of scientific/technical experience OR Master's degree and between 7 to 10 years of scientific/technical experience
• Strong background in innate immunity
• Track record of scientific excellence in immunology
• Highly skilled with biomarker assay platforms such as immunoassays (ADCC, ADCP, ELISPOT, ELISA, Luminex, MSD).
• Proficiency in multiparametric flow cytometry assays including immunophenotyping and immune based functional assays
• Expertise in primary cell immune isolation, differentiation and characterization from murine tissues and human blood
• Extensive experience in innate immune cell subsets isolation and characterization using multi-color flow cytometry
• Knowledge of trained immunity and systems vaccinology
• Experience with human organoid vaccine models
• Ability to perform complex data analysis and team player with strong communication skills
• Strong time management and organizational skills

Nice-to-Have

• Experience with adjuvant vaccine assay development
• Experience with coding, including writing R and Python scripts
• Solid background in vaccine research, innate immunology, infectious diseases or related fields, and a desire to continue in a laboratory-focused role

Other Job Details

• Work Location Assignment: On Premise
• Relocation package available

The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development