Top Senior Python Jobs in NYC, NY

Leads software engineering projects and developer teams building distributed microservices and full-stack systems. Designs cloud-based solutions using Java, Python, AWS, APIs, databases, Docker, Kubernetes, and related technologies. Collaborates with product managers, mentors engineers, evaluates emerging technology, and delivers enterprise platforms supporting regulatory and customer needs.

Leads software engineering projects and developer teams building distributed microservices and full-stack, cloud-based solutions for risk management and regulatory compliance. Responsibilities include coding and code evaluation, mentoring engineers, collaborating with product managers, adopting emerging technologies, and developing systems using Python, TypeScript, React, AWS, databases, Docker, and Kubernetes.

Design, build, and maintain high-availability backend services and RESTful APIs using Python/Django and PHP. Own production deployments on Kubernetes/EKS and AWS, mentor junior engineers, produce technical documentation, define architecture, track performance metrics, and collaborate with stakeholders to deliver scalable ad-tech platform features.

Design and implement server-side logic and RESTful APIs, manage MongoDB and Redis databases, ensure security and performance, contribute to system design and architecture, review code and scope deliverables, collaborate with Product and Client Success, and maintain documentation.

Leads design, development, testing, troubleshooting, and operational stability for real-time, mission-critical Python systems. Drives AI-assisted engineering practices, cloud-native delivery, automation, resiliency, security, and performance optimization. Evaluates architecture and technology with vendors and internal teams, leads software engineering communities of practice, and coaches engineers on responsible, secure, and compliant use of AI tools and large language models.

Design and develop software solutions, analyze complex problems, and provide support for trading activities in a dynamic environment.

Alaffia Health seeks a Senior Python Engineer to develop AI-driven medical billing applications, focusing on backend API development and data processing. Responsibilities include collaborating across teams, improving observability practices, and ensuring successful project delivery.

Develop scalable backend systems and high-performance data infrastructure using Python, AWS, databases, search technologies, and event-driven microservices. Responsibilities include writing maintainable code, optimizing distributed systems, improving product quality and security, collaborating with full-stack and machine learning engineers, delivering user-facing features, and prototyping new technologies.

Lead design and deliver production-grade trading systems using Python and Java, build AI-native platforms, champion AI-assisted engineering practices, partner with Credit Sales & Trading, support production stability, and drive adoption of secure, automated SDLC and cloud-native solutions.

Designs and develops APIs, system integrations, and AI-agent workflows for enterprise applications. Builds integrations with platforms such as Salesforce and REST APIs, deploys and supports solutions on AWS, and develops AI-powered automation using LLMs, tool calling, and multi-step workflows. The role includes client requirements gathering, troubleshooting, reliability optimization, cross-functional collaboration, and mentoring junior developers.

Designs, develops, deploys, and operates scalable Go and Python microservices in distributed production environments. Responsibilities include API design, Kubernetes deployment, monitoring, scaling, troubleshooting incidents, system architecture, security, testing, code reviews, and continuous improvements to development processes and infrastructure. The role requires end-to-end service ownership, strong Linux and Docker expertise, observability knowledge, and experience with reliability, performance, and CI/CD practices.

Lead backend-focused software architecture and development across distributed systems, data ingestion, experimentation platforms, AI workflows, and product capabilities. Build primarily in Python while contributing to React and TypeScript frontend work. Translate ambiguous product needs into scalable production systems, guide technical direction, partner with product and data teams, mentor engineers, and improve engineering practices.

Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.

Develop and maintain open-source Python frameworks and ML developer tools, architect scalable libraries, grow early-stage projects, build real-time streaming capabilities, integrate modern frontend technologies, and collaborate with open-source contributors and the broader developer community.

Lead development of Python-based quant research and portfolio construction platforms: design, build, test, and operate production-quality code; partner with Quant Research on models, validation, reusable libraries, and AI-assisted engineering practices to improve delivery, security, and resiliency.

Lead full‑stack teams to design and deliver cloud-based, microservices solutions. Mentor engineers, collaborate with product managers, and build scalable systems using Python, ReactJS, AWS, containers, and modern data tools to meet regulatory and customer needs.

Leads the architecture, development, testing, deployment, and production support of scalable full-stack applications. Builds React and TypeScript frontends alongside Go, Java, Python, or Node.js backend services, using AWS, containers, CI/CD, databases, observability, and automated testing. Owns end-to-end delivery, contributes to system design and architecture reviews, resolves complex production issues, mentors engineers, and collaborates with product, design, architecture, and business stakeholders.

Modernize legacy SAS data-processing systems by translating logic into scalable, high-performance Python solutions. Build and optimize large-scale data pipelines using formats including SAS, Parquet, JSON, and SQL. Integrate PostgreSQL, implement parallel processing, automated testing, data validation, and quality assurance, and maintain well-documented code. Collaborate with IT specialists and stakeholders to validate requirements, troubleshoot issues, and deliver cloud-native modernization solutions.

Develop production-grade Python services, pipelines, testing frameworks, and data tools that automate quantitative market and credit risk model lifecycles. Build AI/ML and LLM-enabled documentation, data quality, validation, and workflow capabilities within governed enterprise environments. Collaborate with quants, validators, data engineers, and program leaders while applying secure software engineering, CI/CD, testing, and scalable design practices. Mentor junior developers and contribute to technical design reviews.

Lead the design, development, and operation of production-grade automation, agent frameworks, and CI/CD pipelines supporting documentation, localization, and language operations. Integrate platforms through REST APIs and MCPs, apply LLM capabilities responsibly, improve reliability and scalability, establish reusable standards, and mentor engineers. The role is fully remote in the US, with preferred Eastern or Central time zone availability.

Design and maintain scalable Python backend services, enterprise data integration frameworks, batch pipelines, REST APIs, and AWS cloud-native applications. Build serverless solutions using Lambda, DynamoDB, API Gateway, EventBridge, SQS, and Step Functions. Improve data pipeline observability, resilience, monitoring, and performance while supporting analytics, machine learning, and AI use cases. Collaborate with stakeholders and engineering teams, troubleshoot distributed systems, mentor junior engineers, conduct code reviews, and promote modern development and DevOps practices.

The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.

Build and maintain scalable backend applications, serverless functions, microservices, data workflows, ETL pipelines, and cloud-native architectures using Python and AWS. Manage databases, APIs, batch jobs, and real-time integrations while optimizing performance, scalability, security, compliance, and cost. Collaborate with product, engineering, analytics, and data teams; contribute to architecture, CI/CD, infrastructure automation, development standards, and technical mentorship. Healthcare claims data experience is required.

Build and own full-stack AI applications, data APIs, dashboards, and cloud-native services. Develop Python and Node.js backends, React frontends, AI/ML integrations, RAG pipelines, authentication, API management, testing, CI/CD, and performance improvements. Collaborate with AI/ML engineers, data scientists, product, and design teams to deliver scalable, reliable, intuitive, and responsible AI experiences.

Designs and delivers scalable Java and Python applications for mortgage technology, trading, analytics, workflows, and reporting. Partners with business, risk, product, and technology teams to integrate platforms and improve processes. Oversees development through testing, implementation, and operational support; applies AI and GenAI to automate workflows and analysis. Resolves complex technical initiatives, follows engineering and CI/CD standards, mentors junior staff, and serves as a subject matter expert.